RRP12

Across TCGA patient cohorts, RRP12 mutation is significantly associated with the RNA expression of many other genes, with 2,029 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP12-associated genes across cancer lineages are SKA1, ZWINT, and MIR4765. Each is linked with RRP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both RRP12-to-partner and partner-to-RRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by RRP12-low versus RRP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP12→partner) and Y-score (partner→RRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.493	+1.551	<.001	<.001	3	4
SKCM	ZWINT →	+0.598	+2.591	.001	<.001	3	3
HNSC	MIR4765 →	+0.538	+6.763	<.001	<.001	3	3
UCEC	SLX4 →	+0.367	+2.706	<.001	<.001	3	3
UCEC	PTMAP9 →	+0.538	+1.439	.001	.005	3	3
UCEC	RNU6-218P →	+0.320	+1.505	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,029 associations by consensus.

SKA1 by RRP12 expression — UCEC

Explore this box plot interactively →