RRP1

Across TCGA pan-cancer cohorts, RRP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RRP1 data layer compared with 30 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RRP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RRP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where RRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.386	0.833	<.001	64	view →
PDAC	DFS	Median	II,III,IV	0.277	0.536	<.001	42	view →
LUAD	DFS	Median	III,IV	0.804	0.238	<.001	37	view →
LSCC	DFS	Tertile	II,III,IV	0.920	0.551	.002	21	view →
HNSC	DFS	Tertile	III,IV	0.919	1.000	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RRP1–CCRCC (DFS)

Open the CCRCC breakdown →