RRP1

Across TCGA patient cohorts, RRP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and FoxM1. Each is linked with RRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP1-to-partner and partner-to-RRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RRP1-low versus RRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1→partner) and Y-score (partner→RRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-2.571	.006	.011	3	1
UCEC	eIF4E →	+0.225	+2.584	.022	.011	3	1
UCEC	FoxM1 →	+0.299	+2.584	.013	.011	3	1
UCEC	Heregulin →	-0.135	-2.584	.018	.011	3	1
UCEC	MEK1 →	+0.354	+2.584	.038	.011	3	1
UCEC	Annexin-1 →	+0.619	+2.189	.011	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by RRP1 expression — UCEC

Explore this box plot interactively →