RRP1

Across TCGA cell cohorts, RRP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,261 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RRP1-associated GO terms across cancer lineages are rRNA metabolic process, Ribosomal small subunit biogenesis, and Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with RRP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both RRP1-to-partner and partner-to-RRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA metabolic process grouped by RRP1-low versus RRP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1→partner) and Y-score (partner→RRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	rRNA metabolic process →	+0.114	+0.615	<.001	<.001	3	17
BONE	Ribosomal small subunit biogenesis →	+0.137	+1.240	<.001	<.001	3	17
BLOOD_Myeloma	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.125	+0.761	.002	.002	3	17
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.145	+1.105	<.001	.001	3	16
LUNG_SCLC	Ribosome biogenesis →	+0.108	+0.656	<.001	<.001	3	16
BONE	'de novo' IMP biosynthetic process →	+0.192	+1.469	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,261 associations by consensus.

rRNA metabolic process by RRP1 expression — LUNG_SCLC

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