RRP1

Across TCGA cell cohorts, RRP1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRP1-associated genes across cancer lineages are SCGB2A1, HIGD1C, and WFDC8. Each is linked with RRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP1-to-partner and partner-to-RRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB2A1 grouped by RRP1-low versus RRP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1→partner) and Y-score (partner→RRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SCGB2A1 →	+0.054	+5.201	<.001	.006	3	1
BLOOD_Leukemia	HIGD1C →	+0.064	+5.201	.004	.006	3	1
BLOOD_Lymphoma	WFDC8 →	+0.018	+4.867	<.001	.009	3	1
LARGE_INTESTINE	MROH2B →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TMEM235 →	+0.011	+4.467	<.001	.004	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SCGB2A1 by RRP1 expression — BLOOD_Leukemia

Explore this box plot interactively →