RRN3P2

Across TCGA patient cohorts, RRN3P2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRN3P2-associated genes across cancer lineages are ATM, AMPK_alpha, and Rab25. Each is linked with RRN3P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRN3P2-to-partner and partner-to-RRN3P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RRN3P2-low versus RRN3P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRN3P2→partner) and Y-score (partner→RRN3P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.413	-2.000	.015	.030	3	2
COAD	AMPK_alpha →	-0.237	-2.957	.011	.036	3	1
COAD	Rab25 →	-0.311	-2.991	.022	.036	3	1
COAD	TSC1 →	-0.343	-2.991	.016	.036	3	1
COAD	Tuberin →	-0.351	-2.991	.034	.036	3	1
UCEC	EGFR_pY1068 →	-0.203	-2.115	.031	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by RRN3P2 expression — UCEC

Explore this box plot interactively →