RRM2B

Across TCGA patient cohorts, RRM2B mutation is significantly associated with the RNA expression of many other genes, with 344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRM2B-associated genes across cancer lineages are TAB3P1, LINC01072, and LINC01943. Each is linked with RRM2B in more than 2 cancer types. Because this analysis shows association rather than direction, both RRM2B-to-partner and partner-to-RRM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAB3P1 grouped by RRM2B-low versus RRM2B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2B→partner) and Y-score (partner→RRM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TAB3P1 →	+0.043	+6.681	<.001	<.001	3	3
UCEC	LINC01072 →	+0.105	+2.488	.004	.001	3	2
UCEC	LINC01943 →	+0.438	+3.616	.004	.001	3	1
CESC	PRSS40B →	+0.040	+8.174	<.001	<.001	3	1
CESC	VN1R35P →	+0.093	+5.539	.001	.004	3	1
CESC	YWHAQP9 →	+0.109	+5.669	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 344 associations by consensus.

TAB3P1 by RRM2B expression — READ

Explore this box plot interactively →