RRM2B

Across TCGA pan-cancer cohorts, RRM2B RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RRM2B data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RRM2B RNA is associated with better overall survival. In most high-consensus cancer types, elevated RRM2B expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

KIRC, UVM, and COAD are the cancer types where RRM2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.709	0.542	<.001	64	view →
UVM	DFS	Quartile	III,IV	0.182	0.807	<.001	62	view →
COAD	OS	Tertile	All	0.924	0.790	.003	28	view →
LGG	OS	Median	All	0.376	0.519	<.001	28	view →
LUAD	DFS	Quartile	All	0.875	0.727	<.001	21	view →
BRCA	OS	Quartile	All	0.477	0.629	.005	16	view →
SKCM	OS	Median	All	0.855	0.691	.003	15	view →
HNSC	OS	Quartile	All	0.270	0.529	.018	12	view →
LIHC	DFS	Median	All	0.496	0.586	.029	7	view →
CHOL	DFS	Tertile	III,IV	0.163	0.529	.024	6	view →
GBM	DFS	Quartile	All	0.195	0.454	.007	6	view →
ACC	DFS	Tertile	All	0.271	0.732	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RRM2B–KIRC (OS)

Open the KIRC breakdown →