RRM2B

Across TCGA patient cohorts, RRM2B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRM2B-associated genes across cancer lineages are 14-3-3_beta, JNK2, and MEK1. Each is linked with RRM2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RRM2B-to-partner and partner-to-RRM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RRM2B-low versus RRM2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2B→partner) and Y-score (partner→RRM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.099	-2.973	.023	.035	3	1
UCEC	JNK2 →	+0.217	+2.115	.012	.019	3	1
UCEC	MEK1 →	+0.316	+3.169	.048	.019	3	1
UCEC	STAT3_pY705 →	-0.301	-2.321	.008	.033	3	1
UCEC	TIGAR →	+0.179	+1.611	.007	.043	3	1
UCEC	XBP1 →	-0.168	-3.156	.006	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by RRM2B expression — UCEC

Explore this box plot interactively →