RRM2B

Across TCGA cell cohorts, RRM2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,507 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RRM2B-associated GO terms across cancer lineages are DNA synthesis involved in DNA repair, Positive regulation of G0 to G1 transition, and Synaptic vesicle lumen acidification. Each is linked with RRM2B in more than 11 cancer types. Because this analysis shows association rather than direction, both RRM2B-to-partner and partner-to-RRM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA synthesis involved in DNA repair grouped by RRM2B-low versus RRM2B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2B→partner) and Y-score (partner→RRM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNA synthesis involved in DNA repair →	+0.091	+1.143	<.001	<.001	3	12
KIDNEY	Positive regulation of G0 to G1 transition →	+0.192	+1.038	<.001	<.001	3	12
SOFT_TISSUE	Synaptic vesicle lumen acidification →	+0.120	+0.890	<.001	<.001	3	12
BLOOD_Lymphoma	Blastocyst growth →	+0.166	+1.413	<.001	<.001	3	11
LUNG_SCLC	Mitochondrial DNA replication →	+0.113	+0.937	<.001	<.001	3	11
SOFT_TISSUE	Deoxyribonucleotide metabolic process →	+0.167	+1.324	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,507 associations by consensus.

DNA synthesis involved in DNA repair by RRM2B expression — LUNG_SCLC

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