RRM2B

Across TCGA cell cohorts, RRM2B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RRM2B-associated genes across cancer lineages are LCE2A, AVP, and ATXN3L. Each is linked with RRM2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RRM2B-to-partner and partner-to-RRM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE2A grouped by RRM2B-low versus RRM2B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2B→partner) and Y-score (partner→RRM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LCE2A →	+0.053	+4.969	<.001	.003	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
SKIN	ATXN3L →	+0.516	+3.347	<.001	.005	3	1
SKIN	GFRA4 →	+0.020	+3.345	<.001	.007	3	1
SKIN	GOLGA6C →	+0.060	+3.791	.007	.007	3	1
SKIN	KRTAP13-1 →	+0.021	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

LCE2A by RRM2B expression — BLOOD_Leukemia

Explore this box plot interactively →