RRM2B

Across TCGA cell cohorts, RRM2B mutation is significantly associated with the mutation status of many other genes, with 1,590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RRM2B-associated genes across cancer lineages are ABHD2, ZNF235, and DHX36. Each is linked with RRM2B in more than 2 cancer types. Because this analysis shows association rather than direction, both RRM2B-to-partner and partner-to-RRM2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD2 grouped by RRM2B-low versus RRM2B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2B→partner) and Y-score (partner→RRM2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ABHD2 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	ZNF235 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	DHX36 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	DDX39B →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	SHANK3 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	FGFR2 →	+5.014	+5.584	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,590 associations by consensus.

ABHD2 by RRM2B expression — BLOOD_Lymphoma

Explore this box plot interactively →