RRM2

Across TCGA patient cohorts, RRM2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,372 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RRM2-associated genes across cancer lineages are CENPM, CDKN3, and GINS1. Each is linked with RRM2 in more than 9 cancer types. Because this analysis shows association rather than direction, both RRM2-to-partner and partner-to-RRM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RRM2 versus CENPM in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2→partner) and Y-score (partner→RRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPM →	+1.051	+0.560	<.001	<.001	3	10
LUAD	CDKN3 →	+1.350	+0.982	<.001	<.001	3	10
LUAD	GINS1 →	+1.302	+0.976	<.001	<.001	3	10
LUAD	MYBL2 →	+1.850	+0.957	<.001	<.001	3	10
UCEC	E2F1 →	+1.320	+0.793	<.001	<.001	3	10
LUAD	CENPI →	+1.261	+0.949	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,372 associations by consensus.

RRM2 vs CENPM — UCEC

Explore this scatter interactively →