RRM2

Across TCGA pan-cancer cohorts, RRM2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of RRM2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RRM2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRM2 is over-expressed in tumor.

LUAD, BLCA, and KIRP are the cancer types where RRM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+3.493	<.001	11	view →
BLCA	All	IV	+3.332	<.001	11	view →
KIRP	All	III,IV	+2.732	<.001	11	view →
KIRC	Male	IV	+2.116	<.001	11	view →
HNSC	Male	All	+2.096	<.001	11	view →
COAD	Female	II,III,IV	+2.056	<.001	11	view →
LUSC	Female	II,III,IV	+4.132	<.001	9	view →
LIHC	Female	II,III,IV	+2.810	<.001	9	view →
THCA	All	III,IV	+1.035	<.001	9	view →
STAD	Female	All	+3.215	<.001	8	view →
UCEC	All	III,IV	+4.442	<.001	6	view →
BRCA	All	III,IV	+3.407	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

RRM2–LUAD

Open the LUAD breakdown →