RRM2

Across TCGA patient cohorts, RRM2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRM2-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with RRM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRM2-to-partner and partner-to-RRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RRM2-low versus RRM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2→partner) and Y-score (partner→RRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.494	+2.115	.001	.019	3	1
UCEC	A-Raf_pS299 →	-0.181	-2.807	<.001	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.162	-2.690	.002	.006	3	1
UCEC	GSK-3_pS9 →	-0.599	-3.321	<.001	.009	3	1
UCEC	ACC1 →	+0.383	+3.013	.015	.018	3	1
UCEC	HER2_pY1248 →	-0.248	-3.906	.034	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eEF2 by RRM2 expression — UCEC

Explore this box plot interactively →