RRM2

Across TCGA cell cohorts, RRM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,867 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRM2-associated GO terms across cancer lineages are Negative regulation of cell cycle phase transition, Negative regulation of cell cycle process, and Regulation of mitotic sister chromatid separation. Each is linked with RRM2 in more than 19 cancer types. Because this analysis shows association rather than direction, both RRM2-to-partner and partner-to-RRM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle phase transition grouped by RRM2-low versus RRM2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM2→partner) and Y-score (partner→RRM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of cell cycle phase transition →	+0.074	+1.460	.005	.006	3	20
BONE	Negative regulation of cell cycle process →	+0.093	+1.972	.003	.002	3	19
SOFT_TISSUE	Regulation of mitotic sister chromatid separation →	+0.155	+1.590	<.001	<.001	3	19
URINARY_TRACT	Positive regulation of mitotic sister chromatid separation →	+0.184	+1.802	<.001	<.001	3	19
PANCREAS	Positive regulation of cell cycle phase transition →	+0.113	+1.831	<.001	<.001	3	19
SOFT_TISSUE	Positive regulation of mitotic cell cycle phase transition →	+0.125	+1.580	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,867 associations by consensus.

Negative regulation of cell cycle phase transition by RRM2 expression — BONE

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