RRM1

Across TCGA pan-cancer cohorts, RRM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RRM1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RRM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RRM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, UCEC, and CCRCC are the cancer types where RRM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.910	1.000	.038	24	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.508	.018	8	view →
CCRCC	OS	Quartile	III,IV	0.132	0.985	.038	7	view →
LSCC	DFS	Tertile	II,III,IV	0.839	0.504	.034	5	view →
LUAD	DFS	Median	II,III,IV	0.944	0.763	.013	4	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RRM1–COAD (DFS)

Open the COAD breakdown →