RRM1

Across TCGA cell cohorts, RRM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,145 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRM1-associated GO terms across cancer lineages are Positive regulation of chromosome condensation, Regulation of nuclear division, and Negative regulation of chromosome segregation. Each is linked with RRM1 in more than 19 cancer types. Because this analysis shows association rather than direction, both RRM1-to-partner and partner-to-RRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of chromosome condensation grouped by RRM1-low versus RRM1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM1→partner) and Y-score (partner→RRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of chromosome condensation →	+0.253	+1.332	.001	<.001	3	20
PANCREAS	Regulation of nuclear division →	+0.127	+1.277	<.001	<.001	3	20
PANCREAS	Negative regulation of chromosome segregation →	+0.163	+1.475	<.001	<.001	3	20
PANCREAS	Regulation of mitotic nuclear division →	+0.129	+1.361	<.001	<.001	3	20
OESOPHAGUS	Centriole replication →	+0.111	+1.017	<.001	.003	3	20
PANCREAS	Negative regulation of cell cycle process →	+0.069	+1.283	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,145 associations by consensus.

Positive regulation of chromosome condensation by RRM1 expression — BLOOD_Myeloma

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