RRM1-AS1

Across TCGA pan-cancer cohorts, RRM1-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RRM1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RRM1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RRM1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

KIRC, UVM, and COAD are the cancer types where RRM1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.502	0.725	<.001	95	view →
UVM	DFS	Tertile	III,IV	0.173	0.802	<.001	33	view →
COAD	OS	Median	III,IV	0.590	0.776	.005	33	view →
BRCA	DFS	Median	All	0.965	0.936	.005	22	view →
SKCM	DFS	Median	III,IV	0.147	0.342	.002	18	view →
ACC	DFS	Tertile	IV	0.048	0.426	.001	15	view →
READ	DFS	Quartile	II,III,IV	0.790	0.382	.007	9	view →
CHOL	DFS	Tertile	IV	0.122	0.791	.045	9	view →
CESC	OS	Quartile	All	0.936	0.811	.006	8	view →
LUAD	DFS	Median	III,IV	0.766	0.530	.030	7	view →
THCA	DFS	Tertile	II,III,IV	0.859	0.921	.015	7	view →
ESCA	OS	Tertile	IV	0.743	0.393	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RRM1-AS1–KIRC (OS)

Open the KIRC breakdown →