RRM1-AS1

Across TCGA pan-cancer cohorts, RRM1-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RRM1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RRM1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRM1-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LUSC are the cancer types where RRM1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRM1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.421	<.001	12	view →
COAD	All	II,III,IV	+0.231	<.001	8	view →
LUSC	All	II,III,IV	+0.315	<.001	6	view →
KIRC	All	All	+0.059	<.001	6	view →
LUAD	Female	All	+0.160	.003	4	view →
BRCA	Female	All	+0.111	.008	4	view →
THCA	Female	II,III,IV	−0.115	.035	2	view →
THCA	Male	All	+0.130	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

RRM1-AS1–HNSC

Open the HNSC breakdown →