RRH

Across TCGA cell cohorts, RRH mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RRH-associated genes across cancer lineages are CCL18, GOT1L1, and PRAMEF7. Each is linked with RRH in more than 1 cancer types. Because this analysis shows association rather than direction, both RRH-to-partner and partner-to-RRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by RRH-low versus RRH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRH→partner) and Y-score (partner→RRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCL18 →	+0.097	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GOT1L1 →	+0.080	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.012	+5.539	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CCL18 by RRH expression — LARGE_INTESTINE

Explore this box plot interactively →