RRH

Across TCGA pan-cancer cohorts, RRH RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RRH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RRH RNA is repressed in tumor relative to normal tissue. In most cancer types RRH is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and THCA are the cancer types where RRH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−0.481	<.001	11	view →
KIRP	All	III,IV	−0.416	<.001	11	view →
THCA	Male	II,III,IV	−0.345	<.001	10	view →
KIRC	Male	III,IV	−0.208	<.001	7	view →
COAD	All	All	+0.126	.001	5	view →
HNSC	All	IV	+0.170	.025	4	view →
STAD	Male	All	+0.153	.027	4	view →
LIHC	Male	All	+0.105	.004	4	view →
CHOL	All	All	+0.376	.001	2	view →
READ	All	All	+0.296	.023	2	view →
LUAD	All	III,IV	−0.189	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RRH–KICH

Open the KICH breakdown →