RRAS2

Across TCGA patient cohorts, RRAS2 mutation is significantly associated with the RNA expression of many other genes, with 241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRAS2-associated genes across cancer lineages are RNU6-756P, SNORD114-18, and RNA5SP252. Each is linked with RRAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAS2-to-partner and partner-to-RRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-756P grouped by RRAS2-low versus RRAS2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAS2→partner) and Y-score (partner→RRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-756P →	+0.333	+7.640	<.001	.009	3	2
UCEC	SNORD114-18 →	+0.321	+2.492	.002	.008	3	2
UCEC	RNA5SP252 →	+0.414	+2.492	.001	.008	3	2
BRCA	RNU6-827P →	+0.314	+9.057	<.001	.003	3	1
BRCA	TSPY25P →	+0.054	+8.471	<.001	.005	3	1
SKCM	BORCS7-ASMT →	+0.017	+5.037	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 241 associations by consensus.

RNU6-756P by RRAS2 expression — BLCA

Explore this box plot interactively →