RRAS2

Across TCGA pan-cancer cohorts, RRAS2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RRAS2 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RRAS2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RRAS2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CHOL show a favorable association.

HNSC, ACC, and PAAD are the cancer types where RRAS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.538	0.807	<.001	103	view →
ACC	DFS	Median	All	0.209	0.670	<.001	91	view →
PAAD	DFS	Median	All	0.183	0.402	<.001	79	view →
LIHC	OS	Tertile	All	0.406	0.622	<.001	55	view →
KIRP	DFS	Median	All	0.792	0.908	.003	19	view →
SARC	OS	Tertile	All	0.745	0.947	.001	17	view →
BLCA	DFS	Median	All	0.478	0.700	.002	15	view →
SKCM	DFS	Tertile	All	0.258	0.174	.017	15	view →
STAD	OS	Tertile	II,III,IV	0.480	0.707	.016	9	view →
PCPG	DFS	Tertile	All	0.679	0.924	.020	9	view →
KICH	OS	Median	III,IV	0.406	0.894	.026	8	view →
COAD	DFS	Quartile	IV	0.348	0.687	.015	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RRAS2–HNSC (OS)

Open the HNSC breakdown →