RRAS2

Across TCGA patient cohorts, RRAS2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRAS2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, p62 Lck ligand, and p70-S6K. Each is linked with RRAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAS2-to-partner and partner-to-RRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by RRAS2-low versus RRAS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAS2→partner) and Y-score (partner→RRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.538	+2.115	.015	.019	3	1
UCEC	p62 Lck ligand →	+0.432	+3.321	.002	.009	3	1
UCEC	p70-S6K →	+0.181	+1.611	.032	.043	3	1
UCEC	STAT3_pY705 →	-0.436	-2.807	<.001	.003	3	1
UCEC	VHL →	-1.048	-2.459	<.001	.019	3	1
UCEC	C-Raf →	+0.132	+3.169	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Acetyl-a-Tubulin-Lys40 by RRAS2 expression — UCEC

Explore this box plot interactively →