RRAGA

Across TCGA pan-cancer cohorts, RRAGA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RRAGA data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RRAGA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RRAGA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where RRAGA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.978	0.892	.017	15	view →
LUAD	DFS	Median	All	0.874	0.934	.017	11	view →
CCRCC	DFS	Median	III,IV	0.391	0.734	.005	8	view →
GBM	DFS	Median	All	0.412	0.928	.008	4	view →
LSCC	OS	Quartile	All	1.000	0.744	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RRAGA–HNSC (DFS)

Open the HNSC breakdown →