RRAGA

Across TCGA pan-cancer cohorts, RRAGA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RRAGA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RRAGA RNA is repressed in tumor relative to normal tissue. In most cancer types RRAGA is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and UCEC are the cancer types where RRAGA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRAGA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.410	<.001	9	view →
THCA	Male	III,IV	−0.498	<.001	9	view →
UCEC	All	All	−1.145	<.001	8	view →
LIHC	All	III,IV	+0.682	<.001	8	view →
LUSC	All	II,III,IV	−0.486	<.001	8	view →
LUAD	Female	All	−0.426	<.001	8	view →
BLCA	Male	All	−0.641	<.001	7	view →
KIRC	Female	All	+0.574	<.001	7	view →
HNSC	Male	III,IV	+0.432	.017	7	view →
CHOL	All	All	+0.808	.002	4	view →
KIRP	All	II,III,IV	+0.490	.030	4	view →
BRCA	Female	All	−0.217	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RRAGA–KICH

Open the KICH breakdown →