RPUSD4

Across TCGA pan-cancer cohorts, RPUSD4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPUSD4 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RPUSD4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPUSD4 expression acts as an unfavorable survival marker.

LIHC, ESCA, and UCEC are the cancer types where RPUSD4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.076	0.553	.002	24	view →
ESCA	DFS	Median	II,III,IV	0.162	0.525	.011	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	OS	Median	II,III,IV	0.383	0.743	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPUSD4–LIHC (DFS)

Open the LIHC breakdown →