RPUSD4

Across TCGA pan-cancer cohorts, RPUSD4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPUSD4 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RPUSD4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RPUSD4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where RPUSD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.948	0.598	.010	20	view →
PDAC	OS	Median	All	0.692	0.353	.008	14	view →
LUAD	DFS	Median	II,III,IV	0.925	0.741	.030	13	view →
CCRCC	OS	Median	II,III,IV	0.485	1.000	.010	9	view →
COAD	DFS	Median	II,III,IV	1.000	0.914	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPUSD4–LSCC (OS)

Open the LSCC breakdown →