RPUSD3

Across TCGA cell cohorts, RPUSD3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPUSD3-associated genes across cancer lineages are PITX3, IAPP, and OR2C1. Each is linked with RPUSD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPUSD3-to-partner and partner-to-RPUSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITX3 grouped by RPUSD3-low versus RPUSD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPUSD3→partner) and Y-score (partner→RPUSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PITX3 →	+0.155	+3.643	<.001	.005	3	1
LARGE_INTESTINE	IAPP →	+0.535	+3.906	<.001	.005	3	1
LARGE_INTESTINE	OR2C1 →	+0.151	+3.725	<.001	.008	3	1
LARGE_INTESTINE	MAGEB10 →	+0.072	+3.345	<.001	.007	3	1
LARGE_INTESTINE	NCR3 →	+0.153	+3.554	<.001	.007	3	1
LARGE_INTESTINE	TECRL →	+0.014	+3.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PITX3 by RPUSD3 expression — LARGE_INTESTINE

Explore this box plot interactively →