Across TCGA cell cohorts, RPTN RNA expression is significantly associated with the RNA expression of many other genes, with 780 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RPTN-associated genes across cancer lineages are SPRR2E, PGLYRP3, and KRT6C. Each is linked with RPTN in more than 5 cancer types. Because this analysis shows association rather than direction, both RPTN-to-partner and partner-to-RPTN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPTN→partner) and Y-score (partner→RPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPRR2E →	+3.601	+1.371	<.001	.009	2	6
UPPER_AERODIGESTIVE_TRACT	PGLYRP3 →	+1.480	+0.764	<.001	.008	1	6
LUNG_NSCLC_LUSC	KRT6C →	+1.852	+0.232	<.001	<.001	3	4
BLOOD_Myeloma	KRTAP10-9 →	+0.051	+0.014	.009	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SLURP2 →	+3.512	+1.467	<.001	.007	1	5
BLOOD_Leukemia	FAM47B →	+0.008	+0.029	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 780 associations by consensus.

Exploration

RPTN survival (RNA) · tumor vs normal (RNA) · all RPTN data types