RPSA

Across TCGA pan-cancer cohorts, RPSA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPSA data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RPSA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RPSA expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where RPSA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
CCRCC	OS	Tertile	III,IV	0.588	0.912	.001	8	view →
PDAC	DFS	Quartile	All	0.974	0.688	.007	5	view →
LUAD	DFS	Median	All	0.968	0.833	.011	4	view →
GBM	DFS	Quartile	All	0.269	0.481	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPSA–HNSC (OS)

Open the HNSC breakdown →