RPS6P12

Across TCGA pan-cancer cohorts, RPS6P12 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RPS6P12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPS6P12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS6P12 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and UCEC are the cancer types where RPS6P12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6P12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.342	<.001	11	view →
BLCA	All	III,IV	+0.656	<.001	9	view →
UCEC	All	All	+0.493	<.001	8	view →
LUAD	All	All	+0.259	.001	4	view →
STAD	All	All	+0.248	.002	4	view →
LUSC	All	All	+0.291	<.001	3	view →
COAD	All	All	+0.096	.033	3	view →
LIHC	All	All	+0.027	.004	3	view →
ESCA	All	II,III,IV	+0.934	.004	2	view →
THCA	Female	All	−0.073	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RPS6P12–HNSC

Open the HNSC breakdown →