RPS6KC1

Across TCGA patient cohorts, RPS6KC1 mutation is significantly associated with the RNA expression of many other genes, with 4,502 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KC1-associated genes across cancer lineages are RPL17P50, ZNHIT3, and CDK1. Each is linked with RPS6KC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RPS6KC1-to-partner and partner-to-RPS6KC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17P50 grouped by RPS6KC1-low versus RPS6KC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KC1→partner) and Y-score (partner→RPS6KC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL17P50 →	+0.416	+3.191	<.001	<.001	3	5
UCEC	ZNHIT3 →	+0.441	+2.390	<.001	<.001	3	4
UCEC	CDK1 →	+0.605	+2.148	.001	<.001	3	4
UCEC	NUDCD2 →	+0.484	+2.699	<.001	<.001	3	4
UCEC	THAP5 →	+0.409	+2.163	.001	.002	3	4
UCEC	REXO5 →	+0.323	+1.856	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,502 associations by consensus.

RPL17P50 by RPS6KC1 expression — UCEC

Explore this box plot interactively →