RPS6KB1

Across TCGA patient cohorts, RPS6KB1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KB1-associated genes across cancer lineages are ASNS, EGFR_pY1068, and A-Raf_pS299. Each is linked with RPS6KB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KB1-to-partner and partner-to-RPS6KB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RPS6KB1-low versus RPS6KB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB1→partner) and Y-score (partner→RPS6KB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.503	+2.222	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.335	-2.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.112	-1.906	.009	.015	3	1
UCEC	ERK2 →	+0.236	+3.459	<.001	.005	3	1
UCEC	FASN →	+0.297	+1.584	.036	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.105	-1.575	.019	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ASNS by RPS6KB1 expression — UCEC

Explore this box plot interactively →