RPS6KB1

Across TCGA cell cohorts, RPS6KB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,408 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RPS6KB1-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Negative regulation of TORC2 signaling, and Epigenetic regulation of gene expression. Each is linked with RPS6KB1 in more than 15 cancer types. Because this analysis shows association rather than direction, both RPS6KB1-to-partner and partner-to-RPS6KB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by RPS6KB1-low versus RPS6KB1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB1→partner) and Y-score (partner→RPS6KB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of beige fat cell differentiation →	+0.188	+1.097	<.001	<.001	3	16
BONE	Negative regulation of TORC2 signaling →	+0.158	+0.466	.002	.002	3	13
BLOOD_Lymphoma	Epigenetic regulation of gene expression →	+0.060	+0.936	<.001	<.001	3	12
STOMACH	Negative regulation of gene expression, epigenetic →	+0.060	+0.607	.001	<.001	3	12
PANCREAS	Centriole-centriole cohesion →	+0.074	+0.753	.002	.004	3	11
STOMACH	Positive regulation of mRNA metabolic process →	+0.054	+0.567	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,408 associations by consensus.

Negative regulation of beige fat cell differentiation by RPS6KB1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →