RPS6KA6

Across TCGA patient cohorts, RPS6KA6 protein abundance is significantly associated with the RNA expression of many other genes, with 5,567 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RPS6KA6-associated genes across cancer lineages are ATP5PDP1, DEPDC5, and CEP128. Each is linked with RPS6KA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA6-to-partner and partner-to-RPS6KA6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RPS6KA6 versus ATP5PDP1 in BRCA, with a Pearson correlation of 0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA6→partner) and Y-score (partner→RPS6KA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP5PDP1 →	+0.300	+0.468	<.001	.007	3	2
UCEC	DEPDC5 →	-0.427	-1.670	<.001	.003	3	1
UCEC	CEP128 →	+0.868	+1.431	.002	.003	3	1
UCEC	VRK1 →	+0.667	+1.533	.002	<.001	3	1
UCEC	RP2 →	+0.459	+1.186	.002	.008	3	1
UCEC	SPAG1 →	+1.176	+1.440	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,567 associations by consensus.

RPS6KA6 vs ATP5PDP1 — BRCA

Explore this scatter interactively →