RPS6KA6

Across TCGA pan-cancer cohorts, RPS6KA6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RPS6KA6 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RPS6KA6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPS6KA6 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

LUAD, UCEC, and BRCA are the cancer types where RPS6KA6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.189	0.414	<.001	64	view →
UCEC	DFS	Median	III,IV	0.398	0.709	.003	50	view →
BRCA	OS	Tertile	III,IV	0.935	0.820	.001	47	view →
KIRC	DFS	Median	All	0.714	0.547	<.001	41	view →
LGG	DFS	Quartile	All	0.774	0.563	<.001	35	view →
LUSC	DFS	Quartile	III,IV	0.413	0.887	<.001	27	view →
UVM	OS	Median	III,IV	0.302	1.000	.008	20	view →
ESCA	OS	Tertile	III,IV	0.629	0.318	.007	20	view →
HNSC	OS	Tertile	III,IV	0.733	0.589	.011	19	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	15	view →
SKCM	OS	Quartile	II,III,IV	0.812	0.604	.003	14	view →
PAAD	DFS	Quartile	All	0.665	0.361	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RPS6KA6–LUAD (DFS)

Open the LUAD breakdown →