RPS6KA6

Across TCGA patient cohorts, RPS6KA6 mutation is significantly associated with the RNA expression of many other genes, with 3,518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA6-associated genes across cancer lineages are TCF19, GTSE1, and SEPTIN14P8. Each is linked with RPS6KA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both RPS6KA6-to-partner and partner-to-RPS6KA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF19 grouped by RPS6KA6-low versus RPS6KA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA6→partner) and Y-score (partner→RPS6KA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCF19 →	+0.496	+1.284	.001	.001	3	4
UCEC	GTSE1 →	+0.669	+2.099	<.001	<.001	3	4
STAD	SEPTIN14P8 →	+0.399	+3.798	.004	.001	3	3
UCEC	R3HCC1 →	+0.418	+1.866	<.001	<.001	3	3
UCEC	PSMD14 →	+0.294	+1.412	.002	<.001	3	3
UCEC	PIMREG →	+0.580	+1.568	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,518 associations by consensus.

TCF19 by RPS6KA6 expression — UCEC

Explore this box plot interactively →