RPS6KA6

Across TCGA patient cohorts, RPS6KA6 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA6-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E1, and eIF4E. Each is linked with RPS6KA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both RPS6KA6-to-partner and partner-to-RPS6KA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RPS6KA6-low versus RPS6KA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA6→partner) and Y-score (partner→RPS6KA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.480	+1.398	.002	.004	3	4
COAD	Cyclin-E1 →	+0.287	+3.008	.027	.019	3	4
UCEC	eIF4E →	+0.193	+1.502	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.324	+1.502	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.718	+2.039	<.001	<.001	3	3
SKCM	HSP70 →	-0.414	-1.794	.031	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Caspase-7-cleavedD198 by RPS6KA6 expression — UCEC

Explore this box plot interactively →