RPS6KA6

Across TCGA cell cohorts, RPS6KA6 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPS6KA6-associated genes across cancer lineages are OR4X2, OR4K1, and GSTA5. Each is linked with RPS6KA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA6-to-partner and partner-to-RPS6KA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by RPS6KA6-low versus RPS6KA6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA6→partner) and Y-score (partner→RPS6KA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
SOFT_TISSUE	OR4K1 →	+0.020	+5.977	<.001	.001	3	1
SOFT_TISSUE	GSTA5 →	+0.021	+4.930	.001	.008	3	1
SOFT_TISSUE	SPANXN4 →	+1.096	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR10S1 →	+0.028	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2M2 →	+0.018	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

OR4X2 by RPS6KA6 expression — SOFT_TISSUE

Explore this box plot interactively →