RPS6KA4

Across TCGA patient cohorts, RPS6KA4 mutation is significantly associated with the RNA expression of many other genes, with 2,841 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA4-associated genes across cancer lineages are BAG3, ZFYVE19, and PPP2R2D. Each is linked with RPS6KA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RPS6KA4-to-partner and partner-to-RPS6KA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BAG3 grouped by RPS6KA4-low versus RPS6KA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA4→partner) and Y-score (partner→RPS6KA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BAG3 →	+0.612	+3.386	.002	.004	3	3
UCEC	ZFYVE19 →	+0.486	+3.483	<.001	.002	3	3
UCEC	PPP2R2D →	+0.321	+3.021	.003	<.001	3	3
UCEC	HAUS4 →	+0.559	+3.000	.003	.001	3	3
UCEC	SSRP1 →	+0.672	+3.021	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.578	+2.595	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,841 associations by consensus.

BAG3 by RPS6KA4 expression — UCEC

Explore this box plot interactively →