RPS6KA2

Across TCGA patient cohorts, RPS6KA2 mutation is significantly associated with the RNA expression of many other genes, with 4,691 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA2-associated genes across cancer lineages are YARS2, EFL1, and HMG20B. Each is linked with RPS6KA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RPS6KA2-to-partner and partner-to-RPS6KA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YARS2 grouped by RPS6KA2-low versus RPS6KA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA2→partner) and Y-score (partner→RPS6KA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YARS2 →	+0.340	+2.595	.001	<.001	3	4
COAD	EFL1 →	+0.471	+3.605	<.001	.001	3	4
UCEC	HMG20B →	+0.461	+4.480	<.001	<.001	3	4
LUSC	ADPRM →	+0.442	+3.345	.002	.005	3	3
UCEC	PHF5A →	+0.483	+2.440	<.001	<.001	3	3
COAD	ERI1 →	+0.612	+3.584	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,691 associations by consensus.

YARS2 by RPS6KA2 expression — UCEC

Explore this box plot interactively →