RPS6KA2

Across TCGA pan-cancer cohorts, RPS6KA2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPS6KA2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RPS6KA2 RNA is repressed in tumor relative to normal tissue. In most cancer types RPS6KA2 is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

LUSC, BLCA, and LUAD are the cancer types where RPS6KA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6KA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−2.928	<.001	8	view →
BLCA	Male	All	−2.028	<.001	8	view →
LUAD	Male	All	−0.946	<.001	8	view →
KICH	Male	All	−0.982	<.001	7	view →
UCEC	All	All	−1.512	<.001	6	view →
BRCA	All	III,IV	−1.010	<.001	6	view →
KIRP	All	All	−0.660	.001	6	view →
CHOL	All	All	+1.583	<.001	3	view →
LIHC	All	All	+0.463	.004	2	view →
KIRC	All	II,III,IV	−0.305	.033	2	view →
THCA	All	All	+0.271	.022	2	view →
READ	Female	All	−0.932	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPS6KA2–LUSC

Open the LUSC breakdown →