RPS6KA2

Across TCGA patient cohorts, RPS6KA2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KA2-associated genes across cancer lineages are 4E-BP1, eIF4E, and PCNA. Each is linked with RPS6KA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RPS6KA2-to-partner and partner-to-RPS6KA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by RPS6KA2-low versus RPS6KA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA2→partner) and Y-score (partner→RPS6KA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.266	+3.169	.001	.017	3	4
COAD	eIF4E →	+0.177	+2.472	.009	.010	3	3
UCEC	PCNA →	+0.224	+1.485	<.001	.003	3	3
UCEC	PDCD4 →	-0.397	-1.584	.003	.015	3	3
UCEC	STAT3_pY705 →	-0.312	-1.353	<.001	.011	3	3
UCEC	ATM →	-0.487	-1.485	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

4E-BP1 by RPS6KA2 expression — COAD

Explore this box plot interactively →