RPS6KA2

Across TCGA cell cohorts, RPS6KA2 mutation is significantly associated with the RNA expression of many other genes, with 191 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPS6KA2-associated genes across cancer lineages are PRAMEF33, F9, and LCE5A. Each is linked with RPS6KA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KA2-to-partner and partner-to-RPS6KA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF33 grouped by RPS6KA2-low versus RPS6KA2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KA2→partner) and Y-score (partner→RPS6KA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRAMEF33 →	+0.012	+4.415	<.001	.007	3	2
LUNG_SCLC	F9 →	+0.027	+4.643	<.001	.004	3	1
LUNG_SCLC	LCE5A →	+0.632	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

PRAMEF33 by RPS6KA2 expression — SKIN

Explore this box plot interactively →