RPS6KA2-IT1

Across TCGA pan-cancer cohorts, RPS6KA2-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RPS6KA2-IT1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RPS6KA2-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RPS6KA2-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UVM, STAD, and UCEC are the cancer types where RPS6KA2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.417	0.759	<.001	99	view →
STAD	OS	Tertile	All	0.382	0.702	.005	60	view →
UCEC	OS	Median	All	0.560	0.780	<.001	44	view →
KICH	DFS	Quartile	All	0.688	1.000	.013	41	view →
LUSC	OS	Quartile	II,III,IV	0.276	0.601	<.001	31	view →
UCS	DFS	Tertile	III,IV	0.512	0.211	.023	30	view →
OV	OS	Tertile	All	0.773	0.883	<.001	28	view →
HNSC	DFS	Tertile	II,III,IV	0.780	0.634	.005	25	view →
LAML	DFS	Quartile	All	0.595	0.372	.016	24	view →
MESO	OS	Tertile	All	0.284	0.508	.008	16	view →
COAD	OS	Quartile	IV	0.765	0.253	.009	12	view →
LIHC	DFS	Tertile	III,IV	0.165	0.360	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RPS6KA2-IT1–UVM (DFS)

Open the UVM breakdown →