RPS6KA2-IT1

Across TCGA pan-cancer cohorts, RPS6KA2-IT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RPS6KA2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RPS6KA2-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS6KA2-IT1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

HNSC, LUAD, and COAD are the cancer types where RPS6KA2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6KA2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.283	.001	7	view →
LUAD	Male	All	+0.803	<.001	6	view →
COAD	All	II,III,IV	+0.152	.004	6	view →
LUSC	All	II,III,IV	−0.742	<.001	5	view →
UCEC	All	II,III,IV	+0.644	.014	4	view →
CHOL	All	All	+0.272	.008	4	view →
BRCA	Female	All	+0.147	.028	4	view →
READ	Male	All	+0.403	.029	3	view →
PRAD	All	All	+0.308	<.001	2	view →
THCA	All	All	+0.142	.010	2	view →
STAD	Male	All	+0.258	.041	1	view →
LIHC	All	All	+0.071	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RPS6KA2-IT1–HNSC

Open the HNSC breakdown →