RPS6

Across TCGA patient cohorts, RPS6 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6-associated genes across cancer lineages are ACC1, p70-S6K, and eEF2. Each is linked with RPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6-to-partner and partner-to-RPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by RPS6-low versus RPS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6→partner) and Y-score (partner→RPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.414	+2.820	.009	.035	3	2
UCEC	p70-S6K →	+0.179	+3.189	.033	.010	3	2
UCEC	eEF2 →	+0.515	+2.459	<.001	.019	2	2
BLCA	IRS1 →	-0.227	-3.321	.016	.010	3	1
BLCA	Bcl-xL →	+0.193	+3.012	.039	.018	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ACC1 by RPS6 expression — UCEC

Explore this box plot interactively →