RPS4Y1

Across TCGA pan-cancer cohorts, RPS4Y1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RPS4Y1 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RPS4Y1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RPS4Y1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, LSCC, and PDAC are the cancer types where RPS4Y1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.884	0.488	.006	11	view →
LSCC	OS	Quartile	III,IV	0.346	0.986	.006	10	view →
PDAC	DFS	Median	All	0.485	0.323	.009	8	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.289	.022	3	view →
HNSC	DFS	Quartile	III,IV	1.000	0.853	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RPS4Y1–LUAD (DFS)

Open the LUAD breakdown →